Parag Kundu课题组发现老年供体小鼠肠道菌群移植到青年无菌受体小鼠对其神经发生及寿命相关信号起促进作用


   1113日,国际著名学术期刊 Science Translational Medicine 在线发表了中国科学院上海巴斯德研究所发育与健康微生物学研究中心题为“Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice”的最新研究成果。该研究由中心的Parag Kundu研究员主导的来自中国、新加坡、澳大利亚及英国的国际化研究组完成。Parag Kundu研究员与新加坡南洋理工大学(NTU, Singapore)的Sven Pettersson教授为共同通讯作者。 

  Researchers in Institut Pasteur of Shanghai revealed microbiota transplant from aged hosts confers beneficial effects in young mice 

  Transplantation of gut microbiota from aged hosts was shown to have beneficial effects in young recipient mice lacking indigenous microbiota by an international team of scientists from Singapore, China, Australia and United Kingdom led by Professor Parag Kundu, who recently joined The Center for Microbes, Development and Health at the Institut Pasteur of Shanghai (China) and Professor Sven Pettersson (NTU, Singapore). This study was reported on the November 13th, issue of Science Translational Medicine. 

  Our gut microbiota evolves continuously as we age while integrating environmental and host intrinsic signals. Such changes in the gut microbiota have been observed in humans as well as in experimental animals. However, the impact of these ageing associated changes in gut microbial communities on host physiology is not clearly understood. In an unique attempt to understand the influence of microbiota on host ageing, these researchers transplanted gut microbiota from old donor mice into young germ free recipient mice. Unexpectedly, they found microbiota from aged donors promotes intestinal growth, neurogenesis in the brain and prolongevity signalling in the young recipients. Microbiome analysis in the young recipients revealed enrichment in the population of microbes producing butyrate, a type of short chain fatty acid. Finally, the group confirmed the role of butyrate by treating sodium butyrate to young mice, which recapitulated the phenotypic changes observed in the young recipients transplanted with old donor microbiota. The results obtained in this study disclose the unique abilities that our gut microbiota possesses to support its eukaryotic counterpart during ageing. 

  The study marks a significant conceptual advancement in our understanding of the role of gut microbiota in host ageing process. These surprising findings hold future for the development of diet or microbiota-based intervention regimens to stimulate our gut microbiota and support metabolic homeostasis during ageing.  

   Full text link: 

  Legend: Microbiota transplants (MT) from young or old mice were performed into germ-free young recipient mice (left panel). Representative images of doublecortin stained neurons in the dentate gyrus of young recipient mice receiving microbiota transplant from young or old donors (right panels). Doublecortin staining is shown in red and DAPI counterstain is blue. The white arrows indicate doublecortin positive neurons and the red boxes indicate area that had been magnified. Scale bars, 100 μm. Kundu et al Science Translational Medicine 2019